Modeling the complex behavior of single cardiomyocytes during and after field stimulation

Modeling the complex behavior of single cardiomyocytes during and after field stimulation

Recently available experimental data resulting from refined high resolution optical potential measurements augment the modeling effort to describe single cell behavior during external field stimulation, in particular the process of cell excitation. Using a simplified cell model based on the Luo-Rudy...

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Bibliographic Details
Published in:IEEE, PISCATAWAY, NJ, (USA). 1993 p. 823
Main Authors: Platzer, D., Windisch, H.
Format: Conference Proceeding Journal Article
Language:English
Published: IEEE 1993
Subjects:
Biomedical optical imaging
Biomembranes
Cardiology
Conductivity
Defibrillation
Optical recording
Particle measurements
Spatial resolution
Stimulated emission
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Summary:Recently available experimental data resulting from refined high resolution optical potential measurements augment the modeling effort to describe single cell behavior during external field stimulation, in particular the process of cell excitation. Using a simplified cell model based on the Luo-Rudy description of membrane currents, we compare the results of simulation studies with experimental evidence. Besides striking similarity in many aspects, there are also note-able discrepancies, e.g. different dispersions of resulting maximum upstroke velocities, that form a challenge to cardiac cell and membrane modeling.
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ISBN:0780313771
9780780313774
DOI:10.1109/IEMBS.1993.978852