Serrated and Microtubular Colorectal Adenomas in Italian Patients. A 5-year Survey

• Published in: Anticancer research Vol. 25; no. 2B; pp. 1353 - 1359
• Main Authors: RUBIO, C. A, NESI, G, MESSERINI, L, ZAMPI, G
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01-03-2005
• Subjects: Adenoma - classification; Adenoma - epidemiology; Adenoma - pathology; Age Factors; Biological and medical sciences; Colorectal Neoplasms - classification; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - pathology; Female; Humans; Italy - epidemiology; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Tumors; Italy; Europe; Human; adenomas; Rectal disease; Patient; microtubular; Colonic disease; Colorectal adenoma; Survey; Cancerology; Serrated; colon; Digestive diseases; Intestinal disease; rectum; Benign neoplasm; Serrated adenoma
• ISSN: 0250-7005; 1791-7530

Colorectal adenomas from 1552 Italian patients were histologically classified into tubular (TAs), tubulo-villous (TVAs), villous
(VAs), serrated (SAs) and microtubular (MTAs). The purpose was to compare the results to those in 3135 colorectal adenomas
from Swedish patients. Of the 1552 adenomas, 827 (53%) were TAs, 352 (23%) TVAs, 196 (12%) VAs, 102 (7%), SAs and 14 (0.9%)
MTAs. The remaining 61 (4%) were of combined phenotypes (COMBAs). The percentage of VA (considered as the most important dysplastic
precursor of colorectal cancer) was higher in Florence than in Stockholm. Notably, the incidence of colorectal cancer in males
was also higher in Florence (78.6/10 5 ) than in Stockholm (57.2/10 5 ). Notwithstanding, the highest rate of submucosal invasion (7%) was found among SAs. The diameter of the largest section
was used to define the size of the largest adenoma in individual patients. Of the 1380 neoplasias measuring ≤12 mm, only 0.9%
(n=13) had invasive carcinomas, but as many as 8.1% (n=14) of the 172 neoplasias measuring ≥13 mm. SAs and MTAs are special
adenoma phenotypes with particular morphological and cell proliferative attributes at variance from those of TAs, VAs or TVAs.
In the light of the present results, it is proposed that SAs and MTAs are included in future reports of colorectal adenomas
in order to compare their frequency worldwide.