Apolipoprotein A1-derived amyloid in human aortic atherosclerotic plaques

Amyloid deposits in the aortic intima are very common in association with atherosclerosis and aging. In the present study, a major fibril protein purified from amyloid present in human atherosclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein AI. Although senile f...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 147; no. 5; pp. 1186 - 1192
Main Authors:	Westermark, P, Mucchiano, G, Marthin, T, Johnson, KH, Sletten, K
Format:	Journal Article
Language:	English
Published:	United States ASIP 01-11-1995
Subjects:	Aged Aged, 80 and over Amino Acid Sequence Amyloid - isolation & purification Aorta, Thoracic - chemistry Aorta, Thoracic - pathology Apolipoprotein A-I - isolation & purification Arteriosclerosis - metabolism Arteriosclerosis - pathology Humans Immunohistochemistry MEDICIN MEDICINE Middle Aged Molecular Sequence Data
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Summary:	Amyloid deposits in the aortic intima are very common in association with atherosclerosis and aging. In the present study, a major fibril protein purified from amyloid present in human atherosclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein AI. Although senile form of localized apolipoprotein AI-derived amyloidosis has recently been documented in pulmonary vessels of dogs, this is the first example of a localized human amyloid derived from this apolipoprotein.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9440 1525-2191 1525-2191