Primary intracranial CNS lymphoma: MR manifestations

• Published in: American journal of neuroradiology : AJNR Vol. 10; no. 4; pp. 725 - 729
• Main Authors: Schwaighofer, BW, Hesselink, JR, Press, GA, Wolf, RL, Healy, ME, Berthoty, DP
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL Am Soc Neuroradiology 01-07-1989; American Society of Neuroradiology
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - diagnosis; Adult; Aged; AIDS/HIV; Biological and medical sciences; Brain Neoplasms - diagnosis; Central Nervous System Diseases - diagnosis; Female; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma - diagnosis; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Research Support, Non-U.S. Gov't; Infection; Human; Brain; Immunopathology; Nervous system diseases; Viral disease; Central nervous system; AIDS; Hemopathy; Nuclear magnetic resonance imaging; Lymphoma
• ISSN: 0195-6108; 1936-959X

We reviewed MR scans of 10 patients with biopsy-proved primary CNS lymphoma. Twenty-five lesions were identified in 10 patients (four with AIDS and six without AIDS). In general, the typical lesion of CNS lymphoma was found to have the following MR characteristics: they were slightly hypointense on T1-weighted images and slightly hyperintense on proton density and T2-weighted images relative to gray matter; they induced mild edema and mild to moderate mass effect. In AIDS patients, 82% of the lesions were smaller than 2 cm in diameter, and were frequently located in the temporal lobes and basal ganglia; they were often multiple. In non-AIDS patients, 75% of the lesions were larger than 2 cm in diameter and were primarily found in the deep parietal lobe; most were solitary.