Tissue distribution of poly(hexyl 2-cyanoacrylate) nanoparticles coated with monoclonal antibodies in mice bearing human tumor xenografts

The tissue distribution of naked and either normal immunoglobulin G or monoclonal antibody (antitumor osteogenic sarcoma)-coated poly(hexyl-2-cyanoacrylate) nanoparticles was studied in mice bearing human tumor xenografts to evaluate the applicability of the systems for tumor targeting. All systems...

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Bibliographic Details
Published in:	The Journal of pharmacology and experimental therapeutics Vol. 230; no. 3; p. 733
Main Authors:	Illum, L, Jones, P D, Baldwin, R W, Davis, S S
Format:	Journal Article
Language:	English
Published:	United States 01-09-1984
Subjects:	Adsorption Animals Antibodies, Monoclonal - immunology Cell Line Cyanoacrylates - administration & dosage Cyanoacrylates - metabolism Humans Immunoglobulin G - metabolism Liver - metabolism Mice Neoplasm Transplantation Osteosarcoma - immunology Tissue Distribution
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Summary:	The tissue distribution of naked and either normal immunoglobulin G or monoclonal antibody (antitumor osteogenic sarcoma)-coated poly(hexyl-2-cyanoacrylate) nanoparticles was studied in mice bearing human tumor xenografts to evaluate the applicability of the systems for tumor targeting. All systems were shown to deposit mainly in the liver and spleen and no significant uptake was found in the tumors for either the naked or antibody-coated nanoparticles.
ISSN:	0022-3565