Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features

Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15,000-dalton monomer protein, GCDFP-15. By the immunoperoxidase technique, GCDFP-15 was localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands...

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Bibliographic Details
Published in:	The American journal of pathology Vol. 110; no. 2; pp. 105 - 112
Main Authors:	Mazoujian, G, Pinkus, GS, Davis, S, Haagensen, DE, Jr
Format:	Journal Article
Language:	English
Published:	United States ASIP 01-02-1983
Subjects:	Adenofibroma - analysis Adenoma - analysis Apocrine Glands - analysis Apolipoproteins Apolipoproteins D Breast Diseases - immunology Breast Neoplasms - analysis Carrier Proteins Female Fibrocystic Breast Disease - immunology Glycoproteins - analysis Gynecomastia - immunology Histocytochemistry Humans Immunochemistry Immunoenzyme Techniques Lacrimal Apparatus - analysis Male Membrane Transport Proteins Salivary Glands - analysis Sweat Glands - analysis
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Summary:	Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15,000-dalton monomer protein, GCDFP-15. By the immunoperoxidase technique, GCDFP-15 was localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, and ear canal. In normal breast tissue, a few individual epithelial cells within lobules and small ducts were focally positive for GCDFP-15. Fourteen of 30 breast carcinomas stained positively for GCDFP-15. Of 16 carcinomas with apocrine features, 12 stained positively. Benign and malignant lesions from other tissues, including lung, colon, ovary, endometrium, stomach, prostate, liver, esophagus, and kidney, revealed no immunoreactivity. The only cells of "non-apocrine" tissues that contained GCDFP-15 were serous cells of the submandibular salivary gland, submucosal glands of the bronchi, and accessory lacrimal glands. Phylogenetically, these tissues have biologic features in common with apocrine glands. This report is the first to characterize GCDFP-15 as a specific tissue marker of apocrine epithelium.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-9440 1525-2191