Suppression of RANTES in children with Plasmodium falciparum malaria

• Published in: Haematologica (Roma) Vol. 91; no. 10; pp. 1396 - 1399
• Main Authors: Were, T, Hittner, JB, Ouma, C, Otieno, RO, Orago, AS, Ong'echa, JM, Vulule, JM, Keller, CC, Perkins, DJ
• Format: Journal Article
• Language: English
• Published: Pavia Haematologica 01-10-2006
• Subjects: Anemias. Hemoglobinopathies; Animals; Biological and medical sciences; Chemokine CCL5 - antagonists & inhibitors; Chemokine CCL5 - biosynthesis; Chemokine CCL5 - blood; Child; Diseases of red blood cells; Female; Hematologic and hematopoietic diseases; Human protozoal diseases; Humans; Infant; Infectious diseases; Malaria; Malaria, Falciparum - blood; Male; Medical sciences; Parasitic diseases; Plasmodium falciparum; Protozoal diseases; Thrombocytopenia - blood; Human; Erythropoiesis; Thrombocytopenia; Protozoa; Apicomplexa; Protozoal disease; Hematology; Malaria; Anemia; RANTES; Hemopathy; Index; Parasitosis; CC chemokine; Infection; Plasmodium falciparum; Platelet; Hematopoiesis; Reticulocyte; Child; reticulocyte production index
• ISSN: 0390-6078; 1592-8721

Department of Pathology, School of Health Sciences, Kenyatta University, Nairobi, Kenya.
Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood malaria. We found that RANTES is decreased during severe MA (p