Phorbol myristate acetate stimulation of lymphocyte guanylate cyclase and cyclic guanosine 3':5'-monophosphate phosphodiesterase and reduction of adenylate cyclase

Human peripheral blood lymphocytes incubated with the tumor promoter and T-cell mitogen phorbol-12-myristate-13-acetate (PMA) had elevated cyclic quanosine 3':5'-monophosphate (cyclic GMP) levels and activities of guanylate cyclase and cyclic GMP phosphodiesterase and reduced activity of a...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 43; no. 1; pp. 150 - 158
Main Authors:	Coffey, R G, Hadden, J W
Format:	Journal Article
Language:	English
Published:	United States 01-01-1983
Subjects:	3',5'-Cyclic-GMP Phosphodiesterases - blood Adenylyl Cyclases - blood Adult Calcium - blood Dose-Response Relationship, Drug Guanylate Cyclase - blood Humans Lymphocytes - drug effects Lymphocytes - enzymology Phorbols - pharmacology Tetradecanoylphorbol Acetate - pharmacology Time Factors
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Summary:	Human peripheral blood lymphocytes incubated with the tumor promoter and T-cell mitogen phorbol-12-myristate-13-acetate (PMA) had elevated cyclic quanosine 3':5'-monophosphate (cyclic GMP) levels and activities of guanylate cyclase and cyclic GMP phosphodiesterase and reduced activity of adenylate cyclase. The results suggest that PMA stimulates cyclic GMP synthesis by a Ca super(2+)-dependent process which, in the membrane, involves one or more lipoxygenase metabolites and that different mechanisms may account for the alterations in the other cyclic nucleotide-metabolizing enzyme activities.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0008-5472