Serial adoptive transfer of experimental autoimmune uveoretinitis in rats

Experimental autoimmune uveoretinitis (EAU) and pinealitis induced by an interphotoreceptor retinoid-binding protein (IRBP)-derived peptide (R4) was serially transferred into naive recipient rats, using spleen cells from recipients of previous "orders" of transfer. The cells initiating the...

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Bibliographic Details
Published in:	Investigative ophthalmology & visual science Vol. 31; no. 7; pp. 1409 - 1412
Main Authors:	Hu, LH, Sanui, H, Wiggert, B, Redmond, TM, Chan, CC, Chader, GJ, Gery, I
Format:	Journal Article
Language:	English
Published:	United States ARVO 01-07-1990
Subjects:	Amino Acid Sequence Animals Autoimmune Diseases - immunology Eye Proteins Immunization, Passive Lymph Nodes - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Male Molecular Sequence Data Peptides - administration & dosage Pineal Gland - immunology Rats Rats, Inbred Lew Retinitis - immunology Retinol-Binding Proteins - administration & dosage Spleen - immunology Uveitis - immunology
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Summary:	Experimental autoimmune uveoretinitis (EAU) and pinealitis induced by an interphotoreceptor retinoid-binding protein (IRBP)-derived peptide (R4) was serially transferred into naive recipient rats, using spleen cells from recipients of previous "orders" of transfer. The cells initiating the disease in recipients of the first order were either lymph node cells from rats immunized against peptide R4, or lymphocytes of a cell line specific toward this peptide. The serial transfer was successfully carried out through as many as four orders of sequential recipients.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0146-0404 1552-5783