Another patient with chromosome 18 deletion syndrome and juvenile rheumatoid arthritis

Previously, 4 children with deletion of the long arm of chromosome 18 and chronic arthritis were reported. We present an 8-year-old girl with arthritis, atrial septal defect, external auditory canal atresia, and developmental delay. She is the fifth child reported with 18q- syndrome and juvenile rhe...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of rheumatology Vol. 31; no. 5; pp. 998 - 1000
Main Authors:	ROSEN, Paul, HOPKIN, Robert J, GLASS, David N, GRAHAM, T. Brent
Format:	Journal Article
Language:	English
Published:	Toronto, ON The Journal of Rheumatology 01-05-2004 Journal of Rheumatology Publishing
Subjects:	Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis, Juvenile - drug therapy Arthritis, Juvenile - genetics Biological and medical sciences Child Chromosome aberrations Chromosome Banding Chromosome Deletion Chromosome Disorders - genetics Chromosome Disorders - pathology Chromosomes, Human, Pair 18 Developmental Disabilities Diseases of the osteoarticular system Ear Canal - abnormalities Ear Canal - surgery Facies Female Heart Septal Defects, Atrial - genetics Heart Septal Defects, Atrial - pathology Heart Septal Defects, Atrial - surgery Humans Inflammatory joint diseases Medical genetics Medical sciences Naproxen - therapeutic use Syndrome Treatment Outcome Human CHROMOSOME DELETION JUVENILE RHEUMATOID ARTHRITIS Diseases of the osteoarticular system Idiopathic Cardiovascular disease Juvenile rheumatoid arthritis Autoimmune disease Intracardiac defect Inflammatory joint disease Congenital disease Delay Chronic Malformation Heart disease External auditory canal Atresia Atrial septal defect Deletion Genetics Arm Child Chromosome 18
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Previously, 4 children with deletion of the long arm of chromosome 18 and chronic arthritis were reported. We present an 8-year-old girl with arthritis, atrial septal defect, external auditory canal atresia, and developmental delay. She is the fifth child reported with 18q- syndrome and juvenile rheumatoid arthritis. Evidence is mounting that genetic loci on chromosome 18 may play a role in the expression of complex autoimmune diseases. Idiopathic arthritis should be considered as a potential additional feature in 18q- syndrome.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0315-162X 1499-2752