The blood-retinal barrier in chloroquine retinopathy

Chloroquine retinopathy can result in devastating loss of vision. To date, there are no effective and reliable methods of detecting the toxicity at an early stage when retinopathy may be reversible. Chloroquine is deposited in the retinal pigment epithelium, which forms part of the blood-retinal bar...

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Bibliographic Details
Published in:	Investigative ophthalmology & visual science Vol. 30; no. 8; pp. 1726 - 1731
Main Authors:	Raines, MF, Bhargava, SK, Rosen, ES
Format:	Journal Article
Language:	English
Published:	Rockville, MD ARVO 01-08-1989 Association for Research in Vision and Ophtalmology
Subjects:	Aged Biological and medical sciences Blood-Retinal Barrier - drug effects Chloroquine - adverse effects Drug toxicity and drugs side effects treatment Female Fluorescein Angiography Fluorometry Humans Hydroxychloroquine - adverse effects Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pigment Epithelium of Eye - drug effects Retinal Diseases - chemically induced Retinal Diseases - pathology Vision Tests Visual Acuity Human Antimalarial Eye disease Blood retinal barrier Retinopathy Toxicity Vitreous body Fluorophotometry
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Summary:	Chloroquine retinopathy can result in devastating loss of vision. To date, there are no effective and reliable methods of detecting the toxicity at an early stage when retinopathy may be reversible. Chloroquine is deposited in the retinal pigment epithelium, which forms part of the blood-retinal barrier (BRB). By vitreous fluorophotometry we have shown that there is breakdown of the BRB in chloroquine retinopathy. However, in asymptomatic patients who had received varying amounts of hydroxychloroquine (up to 1067 g), the BRB remained intact.
ISSN:	0146-0404 1552-5783