Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin

The abilities of the racemic trans-3,4-, 5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor ini...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 39; no. 6 Pt 1; p. 1934
Main Authors:	Slaga, T J, Gleason, G L, DiGiovanni, J, Sukumaran, K B, Harvey, R G
Format:	Journal Article
Language:	English
Published:	United States 01-06-1979
Subjects:	9,10-Dimethyl-1,2-benzanthracene - analogs & derivatives 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Benz(a)Anthracenes - analogs & derivatives Female Mice Neoplasms, Experimental - chemically induced Papilloma - chemically induced Skin Neoplasms - chemically induced Structure-Activity Relationship Tetradecanoylphorbol Acetate - administration & dosage
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Summary:	The abilities of the racemic trans-3,4-, 5,6-, and 8,9-dihydrodiols of 7,12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7,12-dimethylbenz(a)anthracene trans-5,6- and 8,9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene is a proximal carcinogen and that the "bay region" diol-epoxide may be the ultimate carcinogenic form of DMBA.
ISSN:	0008-5472