Impact of exercise training on neuroplasticity-related growth factors in adolescents

• Published in: Journal of musculoskeletal & neuronal interactions Vol. 13; no. 3; pp. 368 - 371
• Main Authors: Pareja-Galeano, H, Brioche, T, Sanchis-Gomar, F, Montal, A, Jovaní, C, Martínez-Costa, C, Gomez-Cabrera, M C, Viña, J
• Format: Journal Article
• Language: English
• Published: Greece International Society of Musculoskeletal and Neuronal Interactions 01-09-2013
• Subjects: Adolescent; Athletes; Brain-Derived Neurotrophic Factor - blood; Cyclic AMP Response Element-Binding Protein - blood; Exercise - physiology; Human health and pathology; Humans; Insulin-Like Growth Factor I - analysis; Leukocytes, Mononuclear - chemistry; Leukocytes, Mononuclear - metabolism; Life Sciences; Male; Neuronal Plasticity - physiology; Neurons and Cognition; Physical Fitness - physiology; Tissues and Organs; peripheral blood mononuclear cells; creb; bdnf; igf 1
• ISSN: 1108-7161

We aimed to determine the effect of exercise training on plasma levels of brain-derived neurotrophic factor (BDNF), and serum insulin-like growth factor-1 (IGF-1) as well as cAMP response element-binding (CREB) activation in peripheral blood mononuclear cells (PBMCs) in adolescents.
Nine trained and seven sedentary male adolescents, matched in age (14.0±2.2 years), were recruited for the study. Trained boys performed higher physical activity levels (expressed both as total energy expenditure and as physical activity energy expenditure) and showed significant bradycardia when compared with sedentary ones.
We found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones. However, no effect of training was found in the activation of CREB in PBMCs.
We demonstrated the increase of neuroplasticity-related proteins due to exercise training in adolescents. Our results emphasize the significance and impact of exercise in this developmental period.