A comparison of the in vitro cytotoxicity of daunorubicin and liposomal daunorubicin in pediatric acute leukemia

Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differ...

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Bibliographic Details
Published in:	Haematologica (Roma) Vol. 91; no. 11; p. 1573
Main Authors:	Goemans, BF, Zwaan, CM, Reinhardt, D, Gibson, BE, Hahlen, K, Kaspers, GJ
Format:	Journal Article
Language:	English
Published:	Italy 01-11-2006
Subjects:	Adolescent Child Child, Preschool Daunorubicin - administration & dosage Daunorubicin - adverse effects Female Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Liposomes - administration & dosage Male
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Summary:	Anthracyclines are effective in the treatment of leukemia, but their use is limited because of cardiotoxicity. Liposomal daunorubicin (L-DNR) is potentially less cardiotoxic than daunorubicin (DNR). We compared in vitro cytotoxicity in pediatric acute leukemia samples and found no significant differences between cytotoxicity of DNR and L-DNR.
ISSN:	0390-6078 1592-8721