Effect of antipsychotic drugs on protein phosphatase activity in cortex and hippocampus of goat brain extract

• Published in: Indian journal of clinical biochemistry Vol. 31; no. S1; p. S96
• Main Authors: Naik, Devaraju K.S. Deepti C, Kalgutkar, Padmaj S, Patil, Preeti K, Aravind, Sarojini R. Bulbule, Shireshi, Nivedita
• Format: Journal Article
• Language: English
• Published: Springer 01-12-2016
• Subjects: Bipolar disorder; Brain; Drugs; Phosphatases; Schizophrenia; Trifluoperazine
• ISSN: 0970-1915

Antipsychotic drugs are a class of psychiatric medications used to manage psychosis, in particular -Schizophrenia and Bipolar disorder. Based on the target receptor on which it acts, and the intensity of side effects, these drugs can be classified into Neuroleptics--ability of a drug to cause a syndrome known as neurolepsis and Dopamine antagonist--differentiate between first generation drugs from second generation drugs (dopamine-serotonin antagonist) based on the general pharmaco-dynamic properties. But the exact mechanism of action of antipsychotic drugs is still unknown. In the current study we tried to explore non specific modulatory effect of antipsychotic drugs such as Olanzapine, Clozapine and Trifluoperazine on the protein phosphatases' activity in the different fractions of hippocampus and cortex of goat brain extract. The Antipsychotic drugs have different modulatory effect on protein phosphatases; this study helps to purify a specific protein phosphatase of interest with which antipsychotic drug interacts.