The Role of [.sup.18]F-FDG PET/CT in Detecting Ovarian Cancer Recurrence in Patients with Elevated CA-125 Levels/CA-125 Duzeylerinde Artis Olan Over Kanserli Hastalarda Rekurrens Saptamada [.sup.18]F-FDG PET/BT'nin Rolu

• Published in: Molecular imaging and radionuclide therapy Vol. 28; no. 1; p. 8
• Main Authors: Cengiz, Arzu, Koc, Zehra Pinar, Kara, Pelin Ozcan, Yurekli, Yakup
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01-02-2019
• Subjects: Brain damage; Cancer diagnosis; Cancer metastasis; Cancer patients; Cancer recurrence; Care and treatment; Comparative analysis; Health aspects; Liver; Liver cancer; Ovarian cancer; Positron emission tomography; Recurrence (Disease); Tomography; Tumors
• ISSN: 2146-1414
• DOI: 10.4274/mirt.galenos.2018.00710

Objectives: To investigate the role of [.sup.18]F-FDG positron emission tomography/computed tomography (PET/CT) in detection of recurrence in ovarian cancer patients with increased CA-125 levels. Methods: Fifty-two patients (30-80 years old, mean: 58.5[+ or -]10.6 years) who had been histopathologically diagnosed with ovarian cancer, underwent [.sup.18]F-FDG PET/CT imaging for re-staging due to elevation of CA-125 levels were included in this retrospective study. [.sup.18]F-FDG PET/CT findings were compared with histopathological, radiological and clinical follow-up results. Results: CA-125 levels ranged between 35.2-2740 U/mL (N: 0-35 U/mL). Recurrent disease was detected in 45 of 52 patients on PET/CT imaging. There were three false negative and one false positive result. In addition to abdominal and pelvic lesions, 14 distant metastatic lesions (brain, lung, liver and bone metastasis) were identified correctly on PET/CT imaging. Sensitivity, specificity, positive and negative predictive value and accuracy of [.sup.18]F-FDG PET/CT were calculated as 94%, 75%, 98%, 50% and 96%, respectively. Conclusion: [.sup.18]F-FDG PET/CT is a useful imaging method that can be used in detection of ovarian cancer recurrence in patients with elevated CA-125 levels. Since this modality offers whole body imaging, distant metastases could be detected in addition to abdominal and pelvic lesions thus contributing to patient management. Keywords: Ovarian cancer, [.sup.18]F-FDG PET/CT, tumor, markers Amac: Bu calismanin amaci, serum CA-125 duzeylerinde artis olan over kanserli hastalarda rekurrens saptamada [.sup.18]F-FDG pozitron emisyon tomografi/bilgisayarli tomografinin (PET/BT) rolunu arastirmaktir. Yontem: Bu retrospektif calismaya histopatolojik olarak over kanseri tanisi almis, CA-125 duzeylerinde artis nedeniyle yeniden evreleme amaciyla [.sup.18]F-FDG PET/BT yapilan 52 hasta (30-80 yas, ortalama: 58,5[+ or -]10,6 yas) dahil edildi. [.sup.18]F-FDG PET/BT bulgulari histopatolojik bulgular veya radyolojik ve klinik izlem sonuclariyla karsilastirildi. Bulgular: CA-125 duzeyleri 35,2-2740 U/mL (N: 0-35 U/mL) araligindaydi. PET/BT goruntulerinde rekurren hastalik 52 hastanin 45'inde gosterildi. Uc yanlis negatif, bir yanlis pozitif sonuc elde edildi. Abdominal ve pelvik lezyonlara ilave olarak 14 uzak metastaz (beyin, akciger, karaciger ve kemik metastazi) PET/BT ile dogru olarak gosterildi. Duyarlilik, ozgulluk, pozitif ve negatif ongoru degeri ve dogruluk sirasiyla %94, %75, %98, %50 ve %96 idi. Sonuc: [.sup.18]F-FDG PET/BT, serum CA-125 duzeylerinde artis olan over kanserli hastalarda rekurrens saptamada kullanilabilecek yararli bir yontemdir. Tum vucut goruntuleme yontemi olmasi nedeniyle abdominal ve pelvik lezyonlarin yaninda uzak metastazlari da saptayarak bu hastalarin izlemine katkida bulunabilir. Anahtar kelimeler: Over kanseri, [.sup.18]F-FDG PET/BT, tumor, belirtecler