CLINICAL AND MICROBIOLOGICAL ASSESSMENT OF NON-SURGICAL TREATMENT OF CHRONIC PERIODONTITIS IN CONTROLLED AND UNCONTROLLED TYPE 2 DIABETIC PATIENTS/KLINICKA I MIKROBIOLOSKA PROCJENA NE-KIRURSKOG LIJECENJA KRONICNOG PARODONTITISA KOD BOLESNIKA S KONTROLIRANOM I NEKONTROLIRANOM SECERNOM BOLESCU TIP 2

• Published in: Acta clinica Croatica (Tisak) Vol. 60; no. 3; p. 406
• Main Authors: Mirnic, Jelena, Duric, Milanko, Nikolic, Nada, Veljovic, Tanja, Gusic, Ivana, Petrovic, Dorde, Milasin, Jelena
• Format: Journal Article
• Language: English
• Published: Klinicki bolnicki centar Sestre milosrdnice 01-09-2021
• Subjects: Blood sugar; Care and treatment; Complications and side effects; Control; Health aspects; Methods; Patient outcomes; Periodontal disease; Periodontics; Risk factors; Type 2 diabetes; Serbia
• ISSN: 0353-9466
• DOI: 10.20471/acc.2021.60.03.10

Chronic periodontitis is a common complication in diabetes. The aim of this study was to evaluate some clinical and microbiological parameters in controlled and uncontrolled type 2 diabetes mellitus (type 2 DM) patients compared to non-diabetic (NDM) individuals, as well as to assess the effect of non-surgical periodontal therapy on these parameters. The study was performed in 61 type 2 DM patients with periodontitis (group 1A: 29 patients having achieved good metabolic control, HbA1c <7%; group 1B: 32 patients with poor metabolic control, HbA1c [greater than or equal to]7%), and 31 NDM individuals suffering from periodontitis. Periodontal indices (plaque index, PI; gingival index, GI; probing pocket depth, PPD; and clinical attachment level, CAL) were measured and subgingival plaque samples were analyzed using polymerase chain reaction prior to treatment initiation and 3 months post-treatment. The results recorded on the majority of measured parameters indicated that differences in treatment success achieved in the three treatment groups were not statistically significant ([DELTA]PI p=0.646; [DELTA]GI p=0.303; and [DELTA]CAL p=0.233). Likewise, comparison of the effectiveness in microorganism reduction revealed no significant differences between DM groups and NDM patients. Therefore, study results supported the hypothesis that periodontal therapy outcome was unaffected by the level of glycemic control in patients with diabetes. Key words: Diabetes mellitus; Periodontal disease/therapy; Glycosylated hemoglobin (HbA1c); Polymerase chain reaction Kronicna parodontopatija je jedna od vrlo cestih komplikacija dijabetesa melitusa (DM). Cilj istrazivanja bio je usporediti klinicke i mikrobioloske parametre osoba s dobrom i losom metabolickom kontrolom DM tip 2 i onih koje ne boluju od DM (NDM) te procijeniti ucinke bazicne terapije parodontopatije na ove parametre. Ispitivanjem su obuhvacene osobe s kronicnom parodontopatijom: 61 bolesnik s DM tip 2 (skupina 1A: 29 ispitanika s dobrom metabolickom kontrolom, HbA1c <7%; skupina 1B: 32 ispitanika s losom metabolickom kontrolom, HbA1c [greater than or equal to]7%) i 31 NDM osoba. Mjerenja indeksa (plak indeks, PI; gingivalni indeks, GI; DPDz, dubina parodontnog dzepa; i gubitak pricvrstka, GP) i mikrobioloska analiza subgingivalnih uzoraka plaka pomocu lancane reakcije polimeraze provedena su na pocetku istrazivanja i 3 mjeseca nakon tretmana. Rezultati vezani za vecinu klinickih parametara pokazuju da nema statisticki znacajnih razlika u uspjehu terapije izmedu tri ispitivane skupine ([DELTA]PI p=0,646; [DELTA]GI p=0,303; [DELTA]CAL p=0,233). Takoder, nije utvrdena znacajna razlika u uspjesnosti eradikacije ispitivanih bakterijskih vrsta izmedu skupina DM i NDM osoba. Navedeni rezultati idu u prilog tezi da razina metabolicke kontrole ne utjece znacajno na uspjeh terapije parodontopatije kod osoba s DM. Kljucne rijeci: Dijabetes melitus; Parodontne bolesti/terapija; Glikozilirani hemoglobin (HbA1c); Lancana reakcija polimeraze