Retinal Thickness Alterations in Patients with Migraine/Migren Hastalarindaki Retina Kalinlik Degisiklikleri

• Published in: Türk nöroloji dergisi Vol. 27; no. 1; p. 69
• Main Authors: Yurtogullari, Sukran, Timur, Inci Elif Erbahceci, Eyidogan, Demet
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01-03-2021
• Subjects: Diagnosis; Medical examination; Migraine; Physiological aspects; Retina; Turkey
• ISSN: 1301-062X
• DOI: 10.4274/tnd.2020.06791

Objective: To investigate the alterations in macula, ganglion cell complex (GCC), ganglion cell layer (GCL), macular and peripapillary retinal nerve fiber layer (pRNFL) thickness values in patients with migraine and to elicit the correlation between thickness and clinical characteristics of migraine disease. Materials and Methods: One hundred sixty-two eyes of 81 patients with migraine (76 eyes of 38 patients with aura and 86 eyes of 43 patients without aura) and 90 eyes of 45 healthy volunteers as the control group were recruited in the study. Macula, GCL, GCC, and RNFL thickness values were measured using optical coherence tomography (OCT). Results: The mean ages of the aura (+) group, aura (-) group, and the control group were 32.5[+ or -]7.7, 35.2[+ or -]7.9, and 33.7[+ or -]7.7 years, respectively (p=0.751). The mean follow-up time of patients with migraine were 6.3[+ or -]3.1 years. The central macular thickness, inner inferior macular thickness, central quadrant of macular RNFL thickness, mean of outer segment GCL thickness, inner inferior and temporal, mean of outer nasal quadrant GCL thickness measurements were found to be thinner in both aura (+) and aura (-) patients with migraine when compared with healthy subjects (p<0.01, p=0.01, p<0.01, p<0.01, p=0.04, p=0.04, p<0.01 and p=0.01, respectively). Conclusion: Although a specific OCT marker for migraine cannot be detected, alterations of pRNFL, GCC, GCL, macular RFNL and macular thickness obtained with OCT may contribute to the understanding of migraine pathophysiology and aid in the assessment of treatment effectiveness. Keywords: Macular thickness, retinal nerve fiber layer, optical coherence tomography, migraine Amac: Migren hastalarinda makula, gangliyon hucre kompleksi (GHK), gangliyon hucre tabakasi (GHT), makular ve peripapiller retina sinir lifi tabakasi (pRSLT) kalinligi degisikliklerini incelemek ve kalinliklar ile migren hastaliginin klinik ozellikleri arasindaki iliskiyi ortaya cikarmaktir. Gerec ve Yontem: Calismaya 81 migren hastasinin 162 gozu (38 aurali hastanin 76 gozu) ve 43 aurasiz hastanin 86 gozu ve kontrol grubu olarak 45 saglikli gonullunun 90 gozu dahil edildi. Makula, GHT, GHK ve RSLT kalinlik degerleri optik koherens tomografi (OKT) ile olculdu. Bulgular: Yas ortalamasi aura (+) grup, aura (-) grup ve kontrol grubu icin sirasiyla 32,5[+ or -]7,7, 35,2[+ or -]7,9 ve 33,7[+ or -]7,7 yildi (p=0,751). Hastalar ortalama 6,3[+ or -]3,1 yildir migren tanisi ile takip edilmekte idi. Saglikli bireylerle karsilastirildiginda hem aura (+) hem aura (-) migren hastalarinda santral makula kalinligi, ic inferior makula kalinligi, santral makular RSLT kalinligi, ortalama dis halka GHT kalinligi ile ic inferior, ic temporal ve dis nazal GHT kalinliklari; inferiotemporal pRSLT kalinligi (p<0,01, p=0,01, p<0,01, p<0,01, p=0,04, p=0,04, p<0,01 ve p=0,01) daha ince bulundu. Sonuc: Migren icin kesin bir OKT belirteci tespit edilemese de OKT ile elde edilen peripapiller RSLT, GHT, GHK, makular RSLT ve makula kalinlik degisiklikleri migren patofizyolojisinin anlasilmasina katki saglayabilir ve tedavi etkinligini degerlendirmeye yardimci olabilir. Anahtar Kelimeler: Makula kalinligi, retina sinir lifi tabakasi, optik koherens tomografi, migren