Effect of plastoquinone derivative 10- on estrous cycle and 17[beta]-estradiol level in rats

Effect of plastoquinone derivative 10- on estrous cycle and 17[beta]-estradiol level in rats

Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus...

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Bibliographic Details
Published in:Biochemistry (Moscow) Vol. 77; no. 12; p. 1382
Main Authors: Chistyakov, V.A, Dem'yanenko, S.V, Alexandrova, A.A, Gutnikova, L.V, Prokof'ev, V.N, Kosheleva, O.N
Format: Journal Article
Language:English
Published: Springer 01-12-2012
Subjects:
Biological products
Estradiol
Phenols
Online Access:Get full text
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Summary:Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17[beta]-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%. DOI: 10.1134/S0006297912120061 Key words: SkQ1, penetrating cations, estradiol, estrous cycle
ISSN:0006-2979
DOI:10.1134/S0006297912120061