Application of H[sub.2]N-Fe[sub.3]O[sub.4] Nanoparticles for Prostate Cancer Magnetic Resonance Imaging in an Animal Model

• Published in: International journal of molecular sciences Vol. 25; no. 19
• Main Authors: Blasiak, Barbara, MacDonald, David, Jasiński, Krzysztof, Cheng, Fong-Yu, Tomanek, Boguslaw
• Format: Journal Article
• Language: English
• Published: MDPI AG 01-10-2024
• Subjects: Chemical properties; Contrast media; Diagnosis; Equipment and supplies; Ferric oxide; Health aspects; Magnetic resonance imaging; Nanoparticles; Prostate cancer; Poland
• ISSN: 1422-0067
• DOI: 10.3390/ijms251910334

This paper presents the efficacy of a contrast agent based on H[sub.2] N-Fe[sub.3] O[sub.4] nanoparticles for the detection of prostate cancer in an animal model using a preclinical 9.4 T MRI system. The relaxivities r[sub.1] and r[sub.2] of the nanoparticles were 6.31 mM[sup.−1] s[sup.−1] and 8.33 mM[sup.−1] s[sup.−1] , respectively. Nanoparticles injected in a concentration of 2 mg Fe/mL decreased the tumor-relative T[sub.1] relaxation across all animals from 100 to 76 ± 26, 85 ± 27, 89 ± 20, and 97 ± 16 12 min 1 h, 2 h, and 24 h post injection, respectively. The corresponding T[sub.1] decrease in muscle tissues was 90 ± 20, 94 ± 23, 99 ± 12, and 99 ± 14. The relative T[sub.2] changes in the tumor were 82 ± 17, 89 ± 19, 97 ± 14, and 99 ± 8 12 min, 1 h, 2 h, and 24 h post injection, respectively, while, for muscle tissues, these values were 95 ± 11, 95 ± 8, 97 ± 6, and 95 ± 10 at the corresponding time points. The differences in the relative T[sub.1] and T[sub.2] were only significant 12 min after injection (p < 0.05), although a decrease was visible at each time point, but it was statistically insignificant (p > 0.05). The results showed the potential application of H[sub.2] N-Fe[sub.3] O[sub.4] nanoparticles as contrast agents for enhanced prostate cancer MRI.