Beta-Catenin in Non-Small Cells Lung Cancer and Its Association with Proteasomes

• Published in: Bulletin of experimental biology and medicine Vol. 168; no. 5; p. 677
• Main Authors: Kolegova, E.S, Shashova, E.E, Kostromitskii, D.N, Dobrodeev, A.Yu, Kondakova, I.V
• Format: Journal Article
• Language: English
• Published: Springer 01-03-2020
• Subjects: Analysis; Ethylenediaminetetraacetic acid; Lung cancer, Non-small cell; Metastasis; Muscle proteins; Proteolysis
• ISSN: 0007-4888
• DOI: 10.1007/s10517-020-04779

We analyzed the content of [beta]-catenin fractions and activity and content of proteasomes in the tissues of patients with non-small cells lung cancer. The content of [beta]-catenin fractions was elevated and proteasome-dependent proteolysis in the tumor tissue was enhanced in comparison with the corresponding unchanged lung tissue. A negative regression relationship of caspase-like activity of proteasomes and a positive correlation between the content of proteasomes and both fractions of [beta]-catenin were found. We hypothesize that proteasomes are involved in the degradation of [beta]-catenin due to caspase-like activity. Key Words: [beta]-catenin; proteasomes; proteolysis; non-small cell lung cancer (NSCLC)