Drug allergies/ Ilac alerjileri

• Published in: Güncel pediatri p. 76
• Main Authors: Kilic, Mehtap, Ozturk, Fadil
• Format: Journal Article
• Language: Turkish
• Published: Galenos Yayinevi Tic. Ltd 01-09-2009
• Subjects: Adverse and side effects; Drugs; Health education; Turkey
• ISSN: 1304-9054

Adverse drug reactions are common, but only 15% are immunologically mediated. As drug use continues to increase, the incidence of drug allergy will also continue to rise. Drug allergies have a significant impact on clinical practice, drug development and public health. One of the significant consequences of allergic drug reactions is causing the use of potentially less effective, more expensive or more toxic drugs in the future. The symptoms may be life threatening. The diagnosis of drug allergies relies on clinical histories, skin tests and a very few validated in-vitro tests. Education of the patient and primary care physician is an important component of management. This article reviews the current understanding in the mechanisms and recognizing methods of drug allergy and the management of patients. Keywords: Drug allergy, pathogenesis, diagnosis, management Istenmeyen ilac reaksiyonlan oldukca sik goruldugu halde sadece %15 kadari immunolojik mekanizmalarla olususr. ilac kullanimi artmaya devam ettikce ilac alerjisi insidansi da artmaya devam edecektir. ilac alerjileri klinik uygulama, ilac gelistirilmesi ve halk sagligi acisindan onemli etkiye sahiptir. Alerjik ilac reaksiyonlarinin onemli sonuclarindan biri olasilikla daha az etkili, daha pahali veya daha toksik ilaclarin kullanimina neden olmasidir. Belirtiler yasami tehdit edebilir. ilac alerjilerinin tanisi klinik oyku, deri testleri ve onaylanmis birkac in vitro teste dayanir. Hasta ve hekimin egitimi tedavinin onemli bir parcasidir. Bu makale ilac alerjilerinin yeni anlasilmis mekanizmalarini, tani yontemlerini ve hasta tedavisini gozden gecirmektedir. Anahtar kelimeler: ilac alerjisi, patogenez, tani, yaklasim