The WHO global programme for vaccines and immunization vaccine trial registry

• Published in: Bulletin of the World Health Organization Vol. 75; no. 4; pp. 295 - 305
• Main Authors: ROBERTSON, S. E, VALL MAYANS, M, HORSFALL, S, WRIGHT, P. F, CLEMENS, J, IVANOFF, B, LAMBERT, P.-H
• Format: Journal Article
• Language: English
• Published: Genève Organisation mondiale de la santé 01-07-1997; World Health Organization
• Subjects: Adolescent; Adult; Annual reports; Bacterial Vaccines; Biological and medical sciences; Child; Child, Preschool; Cholera; Cholera Vaccines; Clinical trials; Clinical Trials as Topic; Collaboration; Developed Countries; Developing Countries; E coli; Epidemiology. Vaccinations; Escherichia coli - immunology; Europe, Eastern; General aspects; Humans; Immunization; Infant; Infant, Newborn; Infectious diseases; International aspects; LDCs; Licenses; Measles; Measles Vaccine; Medical sciences; Middle Aged; Mortality; Poliovirus Vaccine, Inactivated; Population; R&D; Registries; Research & development; Streptococcus pneumoniae - immunology; Tropical diseases; Tropical medicine; Vaccines; Vaccines - adverse effects; Vaccines - immunology; World Health Organization; Europe, Eastern; Human; Immunoprotection; Evaluation; Sanitary program; Multicenter study; Vaccination; Data; Epidemiology; Prevention; Register; Recording; Public health; WHO; Immunization; Health Services; Health; Vaccines; Delivery Of Health Care; Research Methodology; Research And Development; Research Activities; Economic Factors; International Agencies; Technology; Organizations; Un; Primary Health Care; Who
• ISSN: 0042-9686; 1564-0604

In 1995, the WHO Global Programme for Vaccines and Immunization established a Vaccine Trial Registry. As of September 1996, this registry included 50 WHO-supported vaccine trials, of which 25 (50%) were completed studies. The vaccines most frequently tested have been against measles (9 trials), poliovirus (8 trials), cholera (8 trials), enterotoxigenic Escherichia coli (4 trials), and pneumococcus (4 trials). Nearly 80% of these trials have been conducted in developing countries, with the largest number being in Africa. Among the 25 completed trials, outcomes measured were immune response (24 trials), adverse reactions (13 trials), morbidity (4 trials), and mortality (1 trial). WHO's contributions to these studies include direct funding, assistance with study design, site visits, data analysis, vaccine procurement, and vaccine potency testing.