Development DNA methylation in Drosophila melanogaster

Development DNA methylation in Drosophila melanogaster

Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well. Here we show that DNA is me...

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Bibliographic Details
Published in:Nature (London) Vol. 408; no. 6812; pp. 538 - 540
Main Authors: Jaenisch, Rudolf, Lyko, Frank, Ramsahoye, Bernard H
Format: Journal Article
Language:English
Published: London Nature Publishing Group 30-11-2000
Subjects:
Alloys
Chromatography
Cloning
Deoxyribonucleic acid
DNA
DNA methylation
Drosophila melanogaster
Embryonic growth stage
Genomes
Insects
Ovaries
Symmetry
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Summary:Certain cytosine residues of eukaryotic DNA are methylated in inactive regions of the genome. For a long time the fruitfly Drosophila was thought to be an exception, but now the evidence points to the existence of a functional DNA-methylation system in Drosophila as well. Here we show that DNA is methylated, but that Drosophila genomic methylation is restricted to the early stages of embryonic development.
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ISSN:0028-0836
1476-4687
DOI:10.1038/35046205