Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion

Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile, D-galactose, aging in vivo model, as well as an in vitro model of oxidative/hypoxic injury, we established a cerebral ischemia/reperfusio...

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Published in:	Neural regeneration research Vol. 8; no. 6; pp. 514 - 522
Main Authors:	Shang, Yazhen, Zhang, Hong, Cheng, Jianjun, Miao, Hong, Liu, Yongping, Cao, Kai, Wang, Hui
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 25-02-2013 Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd
Subjects:	Bioflavonoids Care and treatment Cerebral ischemia Dehydrogenases Endoplasmic reticulum Flavones Flavonoids Health aspects Ischemia Memory Metabolism Metabolites Neurons Reperfusion injury Rodents Scullcap Surgery Traditional Chinese Medicine and Neural Regeneration Traumatic brain injury Veins & arteries Scutellaria baicalensis Georgi cerebral ischemia/reperfusion lactate dehydrogenase photographs-containing paper traditional Chinese medicine Ca2+-ATPase neuronal damage brain injury neural regeneration neuroregeneration superoxide dismutase grants-supported paper Na+-K+-ATPase malonaldehyde cognitive impairment
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Summary:	Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile, D-galactose, aging in vivo model, as well as an in vitro model of oxidative/hypoxic injury, we established a cerebral ischemia/reperfusion model in rats by middle cerebral artery occlusion. The light/electron microscopic observations found significant neuropathological changes including neuron loss or swelling and rough endoplasmic reticulum injury. Moreover, the activities of lactate dehydrogenase, Na(+)-K(+)-ATPase, Ca(2+)-ATPase and superoxide dismutase were significantly lowered, and the levels of malonaldehyde increased. In addition, the memory of rats worsened. However, treatment with flavonoids from Scutellaria baicalensis Georgi (35, 70 and 140 mg/kg) for 13 days dramatically improved the above abnormal changes. These results suggest that the ability of flavonoids from Scutellaria baicalensis Georgi in attenuating cerebral functional and morphological consequences after cerebral ischemia/reperfusion may be beneficial for the treatment of ischemic brain disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author statements: The manuscript is original, has not been submitted to or is not under consideration by another publication, has not been previously published in any language or any form, including electronic, and contains no disclosure of confidential information or authorship/patent application/funding source disputations. Author contributions: Hui Wang was in charge of funds, designed the study, provided technical support and revised the manuscript. Yazhen Shang was also in charge of funds, performed the experiments with Hong Zhang, and wrote the manuscript. Jianjun Cheng and Hong Miao provided other technical help. All authors approved the final version of the paper.
ISSN:	1673-5374 1876-7958
DOI:	10.3969/j.issn.1673-5374.2013.06.004