PRE-TERMINAL RENAL INSUFFICIENCY IN A PATIENT WITH ENTERIC HYPEROXALURIA: EFFECT OF MEDICAL MANAGEMENT ON RENAL FUNCTION

• Published in: Acta clinica belgica (English ed. Online) Vol. 67; no. 1; pp. 39 - 41
• Main Authors: PIPELEERS, L, WISSING, K. M, PIRSON, Y, COSYNS, J. P, GEERS, C, TIELEMANS, C
• Format: Journal Article
• Language: English
• Published: Gent University Hospital Gent 01-01-2012; Acta Clinica Belgica; Taylor & Francis Ltd
• Subjects: Aged; Biological and medical sciences; Calcium carbonate; Chronic kidney failure; Diet; Disease prevention; Errors of metabolism; Family medical history; Female; Gastrointestinal surgery; General aspects; Humans; Hyperoxaluria - complications; Hyperoxaluria - diagnosis; Hyperoxaluria - therapy; Kidney diseases; Kidney stones; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Oxalates; Oxalic acid; Potassium citrate; Renal failure; Renal Insufficiency - diagnosis; Renal Insufficiency - etiology; Renal Insufficiency - therapy; Urogenital system; Human; Kidney disease; Urinary system disease; Renal function; Enteric hyperoxaluria; Oxalate; oxalate nephropathy; Metabolic diseases; Patient; Enzymopathy; Kidney; Genetic disease; Medicine; Clinical management; Nephropathy; Urinary system; Renal failure; Hyperoxaluria; kidney stones
• ISSN: 1784-3286; 2295-3337
• DOI: 10.2143/ACB.67.1.2062625

Enteric hyperoxaluria causes tubular deposition calcium oxalate crystals and severe chronic interstitial nephritis. We describe a patient with pre-terminal renal failure due to oxalate nephropathy after ileal resection. Increased oral hydration, low oxalate diet, and oral calcium carbonate and potassium citrate supplements resulted in a significant improvement of renal function. During the three-year follow-up, urinary oxalate concentration was repeatedly reduced below the crystallization threshold and serum creatinine decreased from 4.5 to 1.7 mg/dL. This case illustrates the benefit of combining and optimizing dietary and medical management in enteric hyperoxaluria, even in patients with advanced chronic kidney disease.