INVASIVE PULMONARY ASPERGILLOSIS DUE TO A MULTI-AZOLE RESISTANT ASPERGILLUS FUMIGATUS

• Published in: Acta clinica belgica (English ed. Online) Vol. 67; no. 1; pp. 46 - 48
• Main Authors: JEURISSEN, A, COOREMAN, S, VAN KERCKHOVEN, W, VAN LEEMPUT, J, VANHOVE, P, LAGROU, K, HEYTENS, L
• Format: Journal Article
• Language: English
• Published: Gent University Hospital Gent 01-01-2012; Acta Clinica Belgica; Taylor & Francis Ltd
• Subjects: Amphotericin B; Antifungal Agents - therapeutic use; Antiparasitic agents; Aspergillus fumigatus; Azoles - therapeutic use; Biological and medical sciences; Drug dosages; Drug Resistance, Multiple, Fungal; Family medical history; Fungi; General aspects; Genes; Health aspects; Human mycoses; Humans; Infection; Infectious diseases; Intensive care; Invasive Pulmonary Aspergillosis - diagnosis; Invasive Pulmonary Aspergillosis - drug therapy; Invasive Pulmonary Aspergillosis - microbiology; Male; Medical sciences; Middle Aged; Mutation; Mycoses; Mycoses of the respiratory system; Proteins; Pulmonary aspergillosis; Sterols; Transplants & implants; Fungi; Infection; Medicine; Lung disease; Mycosis; Pulmonary aspergillosis; Respiratory disease; Azole derivatives; Multiple resistance; Fungi Imperfecti; Aspergillus fumigatus
• ISSN: 1784-3286; 2295-3337
• DOI: 10.2143/ACB.67.1.2062627

A patient with invasive pulmonary aspergillosis due to an azole-resistant Aspergillus fumigatus is described. Despite treatment change from voriconazole to amphotericin B as soon as the resistance data were available, the patient died. Azole resistance is an emerging problem, which significantly complicates the management of A. fumigatus infections. It should be considered in every patient with an invasive A. fumigatus infection who is not responding to voriconazole therapy.