Bronchospasms caused by intravenous hydrocortisone sodium hemisuccinate (Solu-Cortef) in an aspirin-sensitive asthmatic patient

This is a report of a male patient who had an anaphylaxia-like reaction to hydrocortisone sodium hemisuccinate (Solu-Cortef). A 32-year-old male with aspirin sensitivity was treated for moderate wheezing with 200 mg Solu-Cortef given intravenously. After this treatment, his condition deteriorated ac...

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Bibliographic Details
Published in:	Nihon Kyōbu Shikkan Gakkai zasshi Vol. 31; no. 8; p. 1024
Main Authors:	Yoshikawa, T, Iida, Y, Horiuchi, I, Inaba, S, Terai, T
Format:	Journal Article
Language:	English Japanese
Published:	Japan 01-08-1993
Subjects:	Adult Aspirin - adverse effects Asthma - chemically induced Asthma - drug therapy Bronchial Spasm - chemically induced Drug Hypersensitivity - etiology Humans Hydrocortisone - administration & dosage Hydrocortisone - adverse effects Hydrocortisone - analogs & derivatives Infusions, Intravenous Male
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Summary:	This is a report of a male patient who had an anaphylaxia-like reaction to hydrocortisone sodium hemisuccinate (Solu-Cortef). A 32-year-old male with aspirin sensitivity was treated for moderate wheezing with 200 mg Solu-Cortef given intravenously. After this treatment, his condition deteriorated acutely and he was admitted to our hospital. Intradermal skin tests revealed positive immediate reactions to Solu-Cortef, Saxizon, Solu-Medrol and Predonine. Challenge tests with 100 mg Solu-Cortef and Saxizon injection showed 34% and 27% decrease, respectively in FEV1 15 min after injection. These results suggest that succinylation of steroids resulted in allergic reaction to steroids in this patient.
ISSN:	0301-1542
DOI:	10.11389/jjrs1963.31.1024