Producing hybrid nanofiber‐based on /PAN/Fe3O4/zeolite/nettle plant extract/urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients

• Published in: Journal of biomedical materials research. Part A Vol. 107; no. 8; pp. 1736 - 1743
• Main Authors: Bahramimehr, Faranak, Esmaeili, Akbar
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-08-2019; Wiley Subscription Services, Inc
• Subjects: Acetic acid; Ammonia; Biocompatibility; Blood; Cellulose acetate; Creatinine; Deformation; Dialysis; Drug delivery; Drug delivery systems; Electrospinning; enzyme; Enzymes; Hemodialysis; Iron oxides; Microfluidics; nanofiber; Nanofibers; Plant extracts; Polyacrylonitrile; Polyurethane; Polyurethane resins; Purification; Reagents; Renal failure; Syringes; Toxicity; Urea; Ureas; Urease; Zeolites
• ISSN: 1549-3296; 1552-4965
• DOI: 10.1002/jbm.a.36689

On incidence of kidney failure, the concentration of urea increases and there is need for patients to visit the hospital all through the week for blood purification. However, current hemodialysis has been found to reduce only 66‐75% urea in the blood of patients. The main goal of this article is to observe the effect of biocompatible and high mechanical hemodiafiltration in reducing urea and creatinine within the shortest time frame, using two methods of Nano electrospinning fiber (hybrid and coaxial). Hybrid electrospinning was made by zeolite 940‐HOA(beta), Fe3O4, polyacrylonitrile as well as the addition of nettle plant's leaf extract. Dispersing solution and enzymes were added to two different syringes and was used in making hybrid nanofibers by the electrospinning process. Nessler's Reagent adsorption method was used for measuring the concentration of ammonia after urease enzyme activation. Second coaxial filter was made by the core‐shell electrospinning system and cellulose acetate phthalate (CAP) as well as polyurethane (PU) were utilized. The data show hybrid hemodiafiltration with enzyme coating, decomposed urea and enzymes were activated for two days after electrospinning. The core‐shell filtration can also reduce creatinine. Core‐shell CAP‐PU nanofiber was previously used for intravaginal drug delivery and PU was used as an artificial renal microfluidic chip. Thus, our study focused on using CAP‐PU to reduce creatinine in dialysis patients. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1736–1743, 2019.