Chlamydia trachomatis in patients who used oral contraceptives and had intermenstrual spotting

To identify the incidence of positive assays for direct antigen detection of Chlamydia trachomatis in oral contraceptive (OC) users with and without intermenstrual spotting and in women seeking contraception. We studied 65 women who had used OCs for more than 3 months and who presented with intermen...

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Bibliographic Details
Published in:	Obstetrics and gynecology (New York. 1953) Vol. 81; no. 5 ( Pt 1); p. 728
Main Authors:	Krettek, J E, Arkin, S I, Chaisilwattana, P, Monif, G R
Format:	Journal Article
Language:	English
Published:	United States 01-05-1993
Subjects:	Adult Antigens, Bacterial - analysis Chlamydia Infections - diagnosis Chlamydia Infections - epidemiology Chlamydia trachomatis - isolation & purification Contraceptives, Oral Female Humans Menstrual Cycle - physiology Menstruation Disturbances - epidemiology Menstruation Disturbances - microbiology Prevalence Risk Factors
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Summary:	To identify the incidence of positive assays for direct antigen detection of Chlamydia trachomatis in oral contraceptive (OC) users with and without intermenstrual spotting and in women seeking contraception. We studied 65 women who had used OCs for more than 3 months and who presented with intermenstrual spotting for which no readily demonstrable cause could be identified. They were compared with 65 matched controls who were taking OCs without intermenstrual spotting and who had chlamydia testing because of one or more risk factors, and 65 matched controls seeking contraception. The incidence of positive tests for each group was compared by chi 2 test for independence using the Yates formula. The strength of the relationship was analyzed by determining the Craemer phi coefficient. Nineteen of the 65 women (29.2%) taking OCs for more than 3 months and experiencing bleeding had positive tests, in contrast to seven of 65 matched controls (10.7%) who were also on OCs and who had had chlamydia testing because of vaginitis or new or multiple sexual consorts, and four of 65 women (6.1%) who were screened for C trachomatis before initiation of contraception. The significance level for the chi 2 statistic was P < .01. Intermenstrual bleeding in women previously well regulated on OCs appears to be an added marker for chlamydial infection.
ISSN:	0029-7844