Determination of amezinium in body fluids

Possible approaches to the determination in body fluids of 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate (ameziniummetilsulfate, LU 1631, Regulton), in this study briefly called amezinium, are investigated and the methods developed on the basis of results obtained in pilot experiments descr...

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Bibliographic Details
Published in:	Arzneimittel-Forschung Vol. 31; no. 9a; p. 1589
Main Authors:	Traut, M, Morgenthaler, H, Brode, E
Format:	Journal Article
Language:	English
Published:	Germany 1981
Subjects:	Body Fluids - analysis Chemical Phenomena Chemistry Humans Ion Exchange Pyridazines - analysis Radioisotope Dilution Technique Spectrophotometry, Ultraviolet
Online Access:	Get more information
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Summary:	Possible approaches to the determination in body fluids of 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate (ameziniummetilsulfate, LU 1631, Regulton), in this study briefly called amezinium, are investigated and the methods developed on the basis of results obtained in pilot experiments described. These methods, which are primarily based on radioactive tracer techniques, allow both labelled and unlabelled amezinium to be determined in urine, bile, blood, and plasma in concentrations down to about 2 n/ml. Relative standard deviations of 0.5%-9% and 96-102% accuracy are obtained. Advantages and disadvantages of individual methods for various types of samples are discussed.
ISSN:	0004-4172