Appraisal of the laser diffraction particle-sizing technique

Appraisal of the laser diffraction particle-sizing technique

Laser diffraction is probably the most widely used technique for particle-size analysis in the pharmaceutical industry, with applications from drug development to production and quality control. The nature of particle-size analysis in terms of how particle size itself is defined and how measurements...

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Bibliographic Details
Published in:Pharmaceutical Technology Vol. 29; no. 3; pp. 88 - 96
Main Author: KIPPAX, Paul
Format: Magazine Article Trade Publication Article
Language:English
Published: Duluth, MN Advanstar Communications 01-03-2005
Intellisphere, LLC
MultiMedia Healthcare Inc
Subjects:
Biological and medical sciences
Diffraction
Drinking water
General pharmacology
Laser beams
Lasers
Measurement
Measurement techniques
Medical sciences
Methods
Microscopy
Particle size
Pharmaceutical industry
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Product quality
Quality control
Reproducibility
United States
United States > US
Particle
Pharmaceutical technology
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Description
Summary:Laser diffraction is probably the most widely used technique for particle-size analysis in the pharmaceutical industry, with applications from drug development to production and quality control. The nature of particle-size analysis in terms of how particle size itself is defined and how measurements should be controlled, however, is seldom discussed. This article reviews the laser diffraction technique, addressing the concerns that have been expressed. Although it is recognized that laser diffraction may not be the method of choice for every particle-sizing application, misuse of the technique is to blame for some of the poor comparisons that have been made against other methods of analysis. Laser diffraction can provide precise, rapid results as long as sampling and dispersion are controlled and the requirements of the analysis are correctly understood.
ISSN:1543-2521
2150-7376