Enantiodifferentiation through Frequency-Selective Pure-Shift 1H Nuclear Magnetic Resonance Spectroscopy

• Published in: Chemphyschem Vol. 15; no. 5; pp. 854 - 857
• Main Authors: Castañar, Laura, Pérez-Trujillo, Míriam, Nolis, Pau, Monteagudo, Eva, Virgili, Albert, Parella, Teodor
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 04-04-2014; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Atomic and molecular physics; chemical shift; enantioselectivity; Exact sciences and technology; homodecoupling; Molecular properties and interactions with photons; NMR; nmr spectroscopy; Nuclear magnetic resonance; Nuclear resonance and relaxation; Physics; single pulsed-field-gradient echo; Chemical shift; Coupling constants; Enantioselectivity; single pulsed-field-gradient echo; homodecoupling; Homonuclear decoupling; nmr spectroscopy; Nuclear magnetic resonance; NMR spectra
• ISSN: 1439-4235; 1439-7641
• DOI: 10.1002/cphc.201301130

A frequency‐selective 1D 1H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical‐shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1H NMR resonances appear as resolved 1D singlets without their typical J(HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents.
Going solo: Frequency‐selective 1D 1H nuclear magnetic resonance (NMR) spectroscopy is used for the fast and sensitive determination of chemical‐shift differences between overlapped resonances. Fully homodecoupled 1H NMR peaks appear as resolved 1D singlets that can be exploited for enantiodiscrimination studies.