Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with [alpha]-Ketols: Convergent Construction of Angucycline Ring Systems

Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with [alpha]-Ketols: Convergent Construction of Angucycline Ring Systems

Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with [alpha]-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of typeII polyketide ring systems of the angucycline class.

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 55; no. 4; p. 1493
Main Authors: Saxena, Aakarsh, Perez, Felix, Krische, Michael J
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 22-01-2016
Edition:International ed. in English
Subjects:
Aldehydes
Construction
Construction methods
Convergence
Cycloaddition
Ruthenium
Online Access:Get full text
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Description
Summary:Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with [alpha]-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of typeII polyketide ring systems of the angucycline class.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201509646