Thrombotic thrombocytopenic purpura in the presence of connective tissue disease and HIV infection: a diagnostic and therapeutic challenge in a resourceconstrained setting

Thrombotic thrombocytopenic purpura in the presence of connective tissue disease and HIV infection: a diagnostic and therapeutic challenge in a resourceconstrained setting

Thrombotic thrombocytopenic purpura (TTP) may occur in the presence of other confounding diseases. We present a case of TTP in a patient with connective tissue disease and HIV infection, in whom the diagnosis and management of TTP was challenging. It is important to understand the various underlying...

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Bibliographic Details
Published in:South African medical journal Vol. 106; no. 6; p. 585
Main Authors: Perumal, R, Marais, J.A, Brown, S
Format: Journal Article
Language:English
Published: Health & Medical Publishing Group 01-06-2016
Subjects:
Care and treatment
Diagnosis
HIV infection
Thrombocytopenic purpura
South Africa
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Summary:Thrombotic thrombocytopenic purpura (TTP) may occur in the presence of other confounding diseases. We present a case of TTP in a patient with connective tissue disease and HIV infection, in whom the diagnosis and management of TTP was challenging. It is important to understand the various underlying mechanisms that drive TTP in the presence of these comorbid diseases, so that an appropriate treatment strategy can be initiated. Our patient failed an initial trial of plasma infusion alone, but responded well to plasma exchange. S Afr Med J 2016;106(6):585-588. DOI:10.7196/SAMJ.2016.v106i6.10274
ISSN:0256-9574
DOI:10.7196/SAMJ.2016.v106i6.10274