Assessment of in vivo bone microarchitecture changes in an anti-TNF[alpha] treated psoriatic arthritic patient

• Published in: PloS one Vol. 16; no. 5; p. e0251788
• Main Authors: Soldati, Enrico, Escoffier, Lucas, Gabriel, Sophie, Ogier, Augustin C, Chagnaud, Christophe, Mattei, Jean P, Cammilleri, Serge, Bendahan, David, Guis, Sandrine
• Format: Journal Article
• Language: English
• Published: Public Library of Science 19-05-2021
• Subjects: Antibodies; Care and treatment; Health aspects; Psoriatic arthritis; Viral antibodies; France
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0251788

Psoriatic arthritis (PsA) is an inflammatory rheumatic disease, mediated in part by TNF[alpha] and associated with bone loss. Anti-TNF[alpha] treatment should inhibit this phenomenon and reduce the systemic bone loss. Ultra-high field MRI (UHF MRI) may be used to quantify bone microarchitecture (BM) in-vivo. In this study, we quantified BM using UHF MRI in a PsA patient and followed up the changes related to anti-TNF[alpha] treatment. A non-treated PsA patient with knee arthritis and 7 gender-matched controls were scanned using a gradient re-echo sequence at UHF MRI. After a year of Adalimumab treatment, the patient underwent a second UHF MRI. A PET-FNa imaging was performed before and after treatment to identify and localize the abnormal metabolic areas. BM was characterized using typical morphological parameters quantified in 32 regions of interest (ROIs) located in the patella, proximal tibia, and distal femur. Before treatment, the BM parameters were statistically different from controls in 24/32 ROIs with differences reaching up to 38%. After treatment, BM parameters were normalized for 15 out of 24 ROIs. The hypermetabolic areas disclosed by PET-FNa before the treatment partly resumed after the treatment. Thanks to UHF MRI, we quantified in vivo BM anomalies in a PsA patient and we illustrated a major reversion after one year of treatment. Moreover, BM results highlighted that the abnormalities were not only localized in hypermetabolic regions identified by PET-FNa, suggesting that the bone loss was global and not related to inflammation.