First Description of the Extended Spectrum-Beta-Lactamase Gene bla.sub.CTX-M-109 in Salmonella Grumpensis Strains Isolated from Neonatal Nosocomial Infections in Dakar, Senegal

Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first d...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 6
Main Authors:	Diop, Amadou, Sambe-Ba, Bissoume, Seck, Abdoulaye, Dia, Mouhamadou Lamine, Timbiné, Lassina Gadi, Niang, Aïssatou Ameth, Ndiaye, El Hadji Momar, Sonko, Mouhamadou Abdoulaye, Wane, Abdoul Aziz, Bercion, Raymond, Ndiaye, Ousmane, Cissé, Moussa Fafa, Gassama-Sow, Amy
Format:	Journal Article
Language:	English
Published:	Public Library of Science 29-06-2016
Subjects:	Beta lactamases Care and treatment Cross infection Demographic aspects Health aspects Newborn infants Risk factors Salmonella food poisoning Senegal
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Summary:	Nosocomial infections are very common in African hospitals, particularly in neonatal units. These infections are most often caused by bacteria such as Escherichia coli, Klebsiella spp and Staphylococcus spp. Salmonella strains are rarely involved in nosocomial infections. Here, we report the first description of S. Grumpensis in neonatal infections in Senegal. Seventeen Salmonella strains were isolated from hospitalized infants' stool samples. The following resistance phenotype was described in strains: AMX.sup.R TIC.sup.R CF.sup.R FOX.sup.R CFX.sup.R CTX.sup.R CAZ.sup.R IMP.sup.S ATM.sup.R NA.sup.R NOR.sup.R CIP.sup.R TM.sup.R GM.sup.R TE.sup.R SXT.sup.R . All isolates were susceptible to imipenem, 15 out of 17 produced an extended spectrum ß-lactamase (ESBL). bla.sub.OXA-1, bla.sub.SHV-1, bla.sub.TEM-1, bla.sub.CTX-M1 genes were detected in strains 8, 13, 5 and 8, respectively. bla.sub.CTX-M1 sequencing revealed the presence of blaCTX-M-109. Thirteen of the 17 Salmonella Grumpensis strains were analyzed by PFGE. These 13 isolates belonged to a single pulsotype and were genotypically identical. This is the first report of neonatal S. Grumpensis infections in Senegal, and the first report of blaCTX-M-109 in the genus Salmonella.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0157683