Susceptibility of Candida species isolated from immunocompromised patients to antifungal agents/Sensibilite aux antifongiques des especes de Candida isolees chez des patients immunodeprimes

• Published in: Eastern Mediterranean health journal Vol. 17; no. 5; pp. 425 - 430
• Main Authors: Badiee, P, Alborzi, A, Shakiba, E, Farshad, S, Japoni, A
• Format: Journal Article
• Language: English
• Published: Alexandria World Health Organization 01-05-2011
• Subjects: Antibiotics; Antifungal agents; Candida; Diagnosis; Dosage and administration; Drug therapy; Fungal infections; Fungi; Health aspects; Immunocompromised host; Infections; Studies; Teaching hospitals; Transplants & implants; Iran
• ISSN: 1020-3397; 1020-3397; 1687-1634

This study was carried out from October 2003 to March 2007 to investigate susceptibility patterns to antifungals of Candida strains isolated from 410 immunocompromised patients in Shiraz, Islamic Republic of Iran. Patients were checked for systemic candidiasis. Fungal colonization was determined and clinical samples collected from those patients with clinical signs of infections were examined. The carbohydrate assimilation patterns of all 354 isolates were studied. Susceptibility of the isolates to antifungal agents was determined using the reference broth microdilution method. Candida albicans was the species most often isolated. Voriconazole was highly active against all the isolates. Major resistance to itraconazole was observed in all Candida spp. Regular investigations into antifungal resistance in medical centres is highly recommended as this will result in more efficient management of invasive candidiasis in immunocompromised patients. La presente etude, realisee entre octobre 2003 et mars 2007, a recherche les evolutions de la sensibilite aux antifongiques des souches de Candida isolees chez 410 patients immunodeprimes dans la ville de Chiraz (Republique islamique d'Iran). Tous les patients ont ete examines a la recherche d'une candidose systemique. Une colonisation fongique a ete constatee et les echantillons cliniques preleves chez les patients presentant des signes d'infection ont ete analyses. Le profil d'assimilation des hydrates de carbone de chacun des 354 isolats a ete etudie. La sensibilite des isolats aux antifongiques a ete determinee aux moyens de la methode de reference de microdilution en milieu liquide. Candida albicans s'est revele etre l'espece la plus souvent isolee. Le voriconazole etait hautement actif contre tous les isolats. Une resistance importante de toutes les especes de Candida a l'itraconazole a ete observee. Des analyses regulieres de la resistance aux antifongiques dans les centres medicaux sont fortement recommandees, car les resultats permettront une prise en charge plus efficace de la candidose systemique chez les patients immunodeprimes.