Neurobiological Mechanisms of Resilience in Individuals at High Genetic Risk for Schizophrenia

• Published in: Revista de psiquiatria clínica Vol. 50; no. 6; p. 90
• Main Authors: Bolke, Matthias, Schauer, Edwin
• Format: Journal Article
• Language: English
• Published: Universidade de Sao Paulo, Facultade de Medicina 01-11-2023
• Subjects: Analysis; Brain research; Care and treatment; Genetic aspects; Genetic research; Genetic susceptibility; Neurophysiology; Psychiatric services; Resilience (Personality trait); Risk factors; Schizophrenia; United Kingdom
• ISSN: 0101-6083
• DOI: 10.15761/0101-60830000000713

A significant problem in psychiatry is computation out how some people manage resilience while having a high hereditary risk for schizophrenia. In-depth exploration of the complex neurobiological mechanisms behind this resilience is provided by this study, which reveals a complex interaction between genetics, brain plasticity, and environmental factors. Research explains how neuroplasticity protects against hereditary susceptibility with a thorough assessment of recent findings, including details on the brain's ability to reorganize and compensate. Dopamine, glutamate, and serotonin neurotransmitter systems stand out as key factors that contribute to the precise biochemical environment linked with resilience. Genetic influences, which include both risk and protective variations, offer a special prism through which to study the intricate interaction between susceptibility and resistance. As this field of study develops, its implications for theoretical knowledge and clinical application also grow, opening fresh viewpoints on therapies that tap resilience to lessen the influence of genetic risk factors for schizophrenia. The ability to adapt, recover, and retain psychological well-being in the face of hardship, trauma, or major pressures is referred to as resilience. It involves the capacity to endure and bounce back from trying situations, failures, or bad life events while retaining a largely constant level of mental health and functioning. Instead of avoiding hardship or tough circumstances, resilience involves navigating and coping with them successfully in a way that promotes psychological growth. Keywords: Neurobiological Mechanisms (NM), Resilience (R), High Genetic Risk (HGR), Schizophrenia (S)