Evaluation of mutagenic activities of endosulfan, phosalone, malathion, and permethrin, before and after metabolic activation, in the Ames Salmonella test

• Published in: Bulletin of environmental contamination and toxicology Vol. 38; no. 6; pp. 925 - 933
• Main Authors: Pednekar, M.D, Gandhi, S.R, Netrawali, M.S
• Format: Journal Article
• Language: English
• Published: New York, NY Springer-Verlag 01-06-1987
• Subjects: Animals; Aroclors - pharmacology; Biological and medical sciences; Biotransformation; Chemical mutagenesis; Chlorodiphenyl (54% Chlorine); COMPOSICION; COMPOSITION; Endosulfan - toxicity; FOOD HYGIENE; HIGIENE DE LOS ALIMENTOS; HYGIENE DES ALIMENTS; In Vitro Techniques; INSECTICIDAS; INSECTICIDE; INSECTICIDES; Insecticides - metabolism; Insecticides - toxicity; Malathion - toxicity; Medical sciences; MUTAGENE; Mutagenicity Tests; MUTAGENOS; MUTAGENS; Mutagens - metabolism; Organothiophosphorus Compounds - toxicity; Permethrin; PESTICIDE; PESTICIDES; PLAGUICIDAS; Pyrethrins - toxicity; Rats; Rats, Inbred Strains; SALMONELLA; Salmonella typhimurium - genetics; Toxicology; Insecticide; Ames test; Mutagenicity testing; Metabolic activation; Bacteria; Escherichieae; Salmonella typhimurium; Enterobacteriaceae
• ISSN: 0007-4861; 1432-0800
• DOI: 10.1007/BF01609074

The work reported here evaluates the mutagenic activities of commonly used insecticides - endosulfan (organochlorine), phosalone and malathion (organophosphorus) and permethrin (pyrethroid), before and after activation with cecal microbial extract or with liver post-mitochondrial fraction (S9-fraction) of rat, in Ames test with Salmonella typhimurium tester strains TA 97a, TA 98 and TA 100. As far as the authors are aware, no study has yet addressed whether the insecticides mentioned above can be mutagenic following their activation by mammalian cecal microorganisms.