Mechanism of cell destructive action of organophosphorus insecticide phosalone in Clamydomonas reinhardtii algal cells

Stationary phase Clamydomonas reinhardtii cells were exposed to phosalone for 2 h and then either maintained in phosalone or washed and resuspended. No cell loss was seen in the 2 h treatment period for either regime, but both suffered about 50 per cent cell loss in the next 22 h. Alkaline phosphata...

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Bibliographic Details
Published in:	Bulletin of environmental contamination and toxicology Vol. 44; no. 6; pp. 819 - 825
Main Authors:	Netrawali, M.S. (Bhabha Atomic Research Centre, Bombay, India), Gandhi, S.R
Format:	Journal Article
Language:	English
Published:	United States 01-06-1990
Subjects:	ALGAE ALGUE Alkaline Phosphatase - metabolism Cell Membrane - drug effects Cell Survival - drug effects CELLS CELLULE CELULAS Chlamydomonas - drug effects COMPOSE ORGANOPHOSPHORE COMPUESTO ORGANICO DEL FOSFORO INSECTICIDAS INSECTICIDE INSECTICIDES Insecticides - toxicity Interphase - drug effects ORGANOPHOSPHORUS COMPOUNDS Organothiophosphorus Compounds - toxicity Time Factors
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Summary:	Stationary phase Clamydomonas reinhardtii cells were exposed to phosalone for 2 h and then either maintained in phosalone or washed and resuspended. No cell loss was seen in the 2 h treatment period for either regime, but both suffered about 50 per cent cell loss in the next 22 h. Alkaline phosphatase activity in the cells began to decrease after about 30 minutes post-treatment and cell protein leakage began after about two and a half hours. Cell membrane lesions were apparently produced during the next 2 to 3 h permitting protein leakage and resulting in cell destruction.
Bibliography:	T01 H01 9037166 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0007-4861 1432-0800
DOI:	10.1007/BF01702169