Development and characterization of a monoclonal antibody (Aby 6C6) that distinguishes medullary from cortical thymocytes

A hybridoma (6C6) producing antibodies with specificities to canine thymocyte surface antigens was produced using standard fusion techniques. The Aby 6C6 has affinity for medullary thymocytes, bone marrow cells, T- and B-peripheral lymphocytes, and monocytes. The Aby 6C6 appears to have 2 heavy chai...

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Bibliographic Details
Published in:	American journal of veterinary research Vol. 45; no. 3; p. 499
Main Authors:	Krawiec, D R, Muscoplat, C C
Format:	Journal Article
Language:	English
Published:	United States 01-03-1984
Subjects:	Animals Antibodies, Monoclonal - immunology Antibody Specificity Antigens - immunology Bone Marrow - immunology Dogs - immunology Hybridomas - immunology Immunologic Techniques T-Lymphocytes - immunology Thymus Gland - immunology
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Summary:	A hybridoma (6C6) producing antibodies with specificities to canine thymocyte surface antigens was produced using standard fusion techniques. The Aby 6C6 has affinity for medullary thymocytes, bone marrow cells, T- and B-peripheral lymphocytes, and monocytes. The Aby 6C6 appears to have 2 heavy chains with different molecular weights, an isoelectric focusing pattern consistent with monoclonality, and is an immunoglobulin G2b antibody with a kappa light chain.
ISSN:	0002-9645