Pseudotypes of vesicular stomatitis virus with coat antigen of bovine leukaemia virus--VSV (BLV): antigenic surface mosaic and the roles of precipitating antibodies and polycations

The pseudotype particles vesicular stomatitis virus (bovine leukaemia virus) [VSV (BLV)] contain a surface antigenic mosaic, composed of both VSV- and BLV-specific antigens, as demonstrated by increased neutralization by anti-VSV serum after addition of complement or of "second antibody"....

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Bibliographic Details
Published in:	Acta virologica (Anglickâa verze) Vol. 24; no. 3; p. 166
Main Authors:	Závadová, Z, Závada, J
Format:	Journal Article
Language:	English
Published:	Slovakia 01-01-1980
Subjects:	Animals Antibodies, Viral - immunology Antigens, Surface - immunology Antigens, Viral - immunology Chick Embryo DEAE-Dextran - pharmacology Epitopes Hexadimethrine Bromide - pharmacology Leukemia Virus, Bovine - immunology Retroviridae - immunology Vesicular stomatitis Indiana virus - drug effects Vesicular stomatitis Indiana virus - growth & development Vesicular stomatitis Indiana virus - immunology
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Summary:	The pseudotype particles vesicular stomatitis virus (bovine leukaemia virus) [VSV (BLV)] contain a surface antigenic mosaic, composed of both VSV- and BLV-specific antigens, as demonstrated by increased neutralization by anti-VSV serum after addition of complement or of "second antibody". All the pseudotype infectivity was precipitated by VSV-specific antibody: it could be pelleted by low-speed centrifugation and its infectivity recovered without any loss by sonication. Polycations present during adsorption had little effect on infectivity of the pseudotype for Vero cells, but markedly increased its titre for chicken fibroblasts.
ISSN:	0001-723X