Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration

Serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination, trimethoprim-sulfadiazine (1:5). By using a 1-compartment open model, pharmacokinetic parameters for both drugs were estimated from the mean serum concentratio...

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Bibliographic Details
Published in:	American journal of veterinary research Vol. 42; no. 6; p. 996
Main Authors:	Sigel, C W, Ling, G V, Bushby, S R, Woolley, Jr, J L, DeAngelis, D, Eure, S
Format:	Journal Article
Language:	English
Published:	United States 01-01-1981
Subjects:	Administration, Oral Animals Dogs - metabolism Kinetics Male Sulfadiazine - administration & dosage Sulfadiazine - metabolism Sulfadiazine - urine Trimethoprim - administration & dosage Trimethoprim - metabolism Trimethoprim - urine
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Summary:	Serial blood samples were obtained from 12 healthy adult dogs given equivalent subcutaneous and oral doses of the antibacterial combination, trimethoprim-sulfadiazine (1:5). By using a 1-compartment open model, pharmacokinetic parameters for both drugs were estimated from the mean serum concentration data after oral administration. Trimethoprim and sulfadiazine were rapidly absorbed, reaching maximum concentrations in 1 and 4 hours with serum elimination half-lives of 2.5 and 9.9 hours, respectively. After a single oral dose (30 mg/kg, combined ingredients) was given, both drugs were present in urine for up to 24 hours at concentrations exceeding the minimum inhibitory concentrations for common pathogenic bacteria.
ISSN:	0002-9645