Lung volume and compliance in neonatal rats

Lung volumes and static lung compliance were measured in decapitated three day-old neonatal Long Evans' rat pups. Compliance was measured in situ (open chest method) using a water manometer and syringe system. Mean total lung capacity at 20 cm H2O pressure (TLC20) was 0.678 ml. Minimum lung vol...

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Bibliographic Details
Published in:	Laboratory animal science (Chicago) Vol. 34; no. 4; p. 371
Main Authors:	Newman, L M, Johnson, E M, Roth, J M
Format:	Journal Article
Language:	English
Published:	United States 01-08-1984
Subjects:	Animals Animals, Newborn - anatomy & histology Animals, Newborn - physiology Body Weight Lung - anatomy & histology Lung - physiology Lung Compliance Lung Volume Measurements - veterinary Organ Size Rats - anatomy & histology Rats - physiology Total Lung Capacity - veterinary
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Summary:	Lung volumes and static lung compliance were measured in decapitated three day-old neonatal Long Evans' rat pups. Compliance was measured in situ (open chest method) using a water manometer and syringe system. Mean total lung capacity at 20 cm H2O pressure (TLC20) was 0.678 ml. Minimum lung volume after experimental inflation was 0.197 +/- 0.048 ml, and vital capacity was 0.56 ml (Vmax20). The mean lung compliance value for the approximate tidal loop (between 3 and 12 cm H2O) equalled 26.2 microliters air/cm H2O for the inflation limb and 23.1 microliters/cm H2O for the deflation limb.
ISSN:	0023-6764