Circulating lipophages and aortic foam cells in experimental atherosclerosis of rabbits under altered reticuloendothelial activity

Administration of Freund's adjuvant to cholesterol-fed rabbits inhibited the induction of atheroma in the aorta of rabbits when compared with cholesterol-fed indiaink-treated animals and cholesterol-fed saline-treated controls. Simultanously the blockade of the reticuloendothelial system by ind...

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Bibliographic Details
Published in:	Nutrition and metabolism (Basel) Vol. 20; no. 1; p. 14
Main Authors:	Pachauri, S P, Jacotot, B, Beaumont, J L
Format:	Journal Article
Language:	English
Published:	Switzerland 1976
Subjects:	Animals Aorta - cytology Aorta - pathology Arteriosclerosis - blood Arteriosclerosis - pathology Cholesterol - blood Leukocyte Count Lipid Metabolism Macrophages - metabolism Male Mononuclear Phagocyte System Phospholipids - blood Rabbits Triglycerides - blood
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Summary:	Administration of Freund's adjuvant to cholesterol-fed rabbits inhibited the induction of atheroma in the aorta of rabbits when compared with cholesterol-fed indiaink-treated animals and cholesterol-fed saline-treated controls. Simultanously the blockade of the reticuloendothelial system by india ink caused a greater degree of atheromatous lesions in these rabbits. Smears of peripheral blood studied by light microscopy revealed the presence of circulating lipophages which were morphologically similar to the aortic foam cells isolated from the same animal. Isolation of mononuclear lipid-containing foam cells from aortic intima and the presence of a morphologically similar type of cell in circulating blood indicate that the blood might be the most likely source of intimal foam cells.
ISSN:	0029-6678