Simultaneous determination of residual fourteen kinds of beta-lactam and macrolide antibiotics in bovine muscles by high-performance liquid chromatography with a diode array detector

Residues of 14 kinds of beta-lactam and macrolide antibiotics in bovine muscles were extracted with acetonitrile and the extract was partitioned with n-hexane to remove fat. High-performance liquid chromatography was carried out on a TSK-gel ODS-80TM column using gradient elution with acetonitrile-0...

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Bibliographic Details
Published in:	Shokuhin eiseigaku zasshi Vol. 45; no. 3; p. 161
Main Authors:	Nagata, T. (Chiba-ken. Government Office (Japan)), Ashizawa, E, Hashimoto, H
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-06-2004
Subjects:	ANALYTICAL METHODS Animals Anti-Bacterial Agents - analysis ANTIBIOTICS BEEF beta-Lactams - analysis Cattle Chromatography, High Pressure Liquid - methods Drug Residues - analysis DRUGS Food Analysis - methods HPLC Macrolides - analysis Meat - analysis MUSCLES
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Summary:	Residues of 14 kinds of beta-lactam and macrolide antibiotics in bovine muscles were extracted with acetonitrile and the extract was partitioned with n-hexane to remove fat. High-performance liquid chromatography was carried out on a TSK-gel ODS-80TM column using gradient elution with acetonitrile-0.05% trifluoroacetic acid and the drugs were quantitated by diode array detection. The recoveries of the drugs from bovine muscles spiked at 0.1 ppm were over 63% and each quantitation limit was 0.04 ppm.
Bibliography:	2004008219 Q03
ISSN:	0015-6426
DOI:	10.3358/shokueishi.45.161