Comparative neuromuscular blocking effects of vecuronium, pancuronium, Org 6368 and suxamethonium in the anaesthetized domestic pig

The neuromuscular blocking and cardiovascular effects of three competitive neuromuscular blocking drugs, vecuronium, pancuronium and Org 6368, and the depolarizing drug suxamethonium, have been evaluated in the anaesthetized domestic pig. Both the relative time-course and the order of potency of the...

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Bibliographic Details
Published in:	British journal of anaesthesia : BJA Vol. 59; no. 5; p. 622
Main Authors:	Muir, A W, Marshall, R J
Format:	Journal Article
Language:	English
Published:	England 01-05-1987
Subjects:	Anesthesia, General Animals Dose-Response Relationship, Drug Drug Evaluation Female Hemodynamics - drug effects Male Muscle Contraction - drug effects Neuromuscular Blocking Agents - pharmacology Pancuronium - analogs & derivatives Pancuronium - pharmacology Succinylcholine - pharmacology Swine Time Factors Vecuronium Bromide - pharmacology
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Summary:	The neuromuscular blocking and cardiovascular effects of three competitive neuromuscular blocking drugs, vecuronium, pancuronium and Org 6368, and the depolarizing drug suxamethonium, have been evaluated in the anaesthetized domestic pig. Both the relative time-course and the order of potency of the drugs agreed well with published data in man. In addition, the cardiovascular side-effects of pancuronium and Org 6368 were identified readily. These preliminary results suggest that the pig may provide more reliable neuromuscular blocking time-course data than does the more commonly utilized cat model.
ISSN:	0007-0912
DOI:	10.1093/bja/59.5.622