Antibacterial susceptibility patterns and cross-resistance of acinetobacter, isolated from hospitalized patients, Southern Iran

• Published in: Iranian red crescent medical journal Vol. 13; no. 11; pp. 832 - 836
• Main Authors: Farshad, S., Japoni, S., Ali, A. Abdi, Japoni, A.
• Format: Journal Article
• Language: English
• Published: Dubai, United Arab Emirates Iranian Hospital 01-11-2011; Zamen Salamati Publishing; Kowsar
• Subjects: Acinetobacter infections; Antibacterial agents; Short Communication; الراكدة; العدوى; المواد المضادة للبكتيريا; Acinetobacter; Cross resistance; Iran; Antibiotic resistance
• ISSN: 2074-1804; 2074-1812

Background : Acinetobacter is a multi-drug resistant and nosocomial pathogen. The aim of this study was to determine antibacterial susceptibility patterns and cross-resistance of Acinetobacter species. Methods : This study was conducted in Nemazee Hospital, Shiraz, Iran from October 2007 to September 2008. Species identification was carried out by API E20. Minimum inhibitory concentration and cross-resistance of the isolated strains to 12 antibiotics were determined by E-test method. Results : Eighty eight isolates of Acinetobacter were collected from patients’ samples. Acinetobacter baumannii was isolated most frequently (79 ; 89.8 %). Colistin, imipenem and meropenem were found to be the three most effective antibiotics with 97.7 %, 77.3 % and 72.7 % activity against the isolates, respectively. Multi-drug resistance was revealed among 2 to 11 antibiotics and high cross-resistance was also noticed. Conclusion : To alleviate the situation, strict control measures and appropriate effective antibiotic therapy should be adopted to reduce hospital costs and related mortality.