Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism

• Published in: Bioorganic & medicinal chemistry letters Vol. 9; no. 20; pp. 2959 - 2962
• Main Authors: Mashino, Tadahiko, Okuda, Kensuke, Hirota, Takashi, Hirobe, Masaaki, Nagano, Tetsuo, Mochizuki, Masataka
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 18-10-1999; Elsevier
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Carbon - chemistry; Carbon - pharmacology; Escherichia coli - drug effects; Escherichia coli - growth & development; Escherichia coli - metabolism; Medical sciences; Oxygen - metabolism; Oxygen Consumption - drug effects; Pharmacology. Drug treatments; Organic cation; Nitrogen heterocycle; Escherichia coli; In vitro; Quaternary ammonium compound; Water soluble compound; Position isomer; Structure activity relation; Carboxylic acid; Bacteriostasis; Fullerenes; Bacteria; Antibacterial agent; Mechanism of action; Enterobacteriaceae
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(99)00515-6

Cationic ammonium fullerene derivatives (C
60-
bis(
N,
N-dimethylpyrrolidinium iodide) and C
60-
bis(
N-methylpiperazinium iodide)) suppressed
E. coli growth, whereas an anionic derivative (C
60-dimalonic acid) did not. Both cationic derivatives inhibited
E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
Cationic ammonium fullerene derivatives,
2 and
3 suppressed
E. coli growth, whereas an anionic derivative,
1 did not. Both cationic derivatives inhibited
E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
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